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During a three-week treatment period, both Cagrilintide and salmon calcitonin (sCT), another amylin receptor agonist, produced an acute reduction in food intake in WT mice on day 1 by 53% and 42%, respectively, but not in RAMP1/3 KO mice

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The metabolic profiling revealed that AOD9604 undergoes rapid proteolytic degradation in serum, generating a series of predictable fragment peptides

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